Tumor staging but not grading is associated with adverse clinical outcome in neuroendocrine tumors of the appendix: a retrospective clinical pathologic analysis of 138 cases.

@article{Volante2013TumorSB,
  title={Tumor staging but not grading is associated with adverse clinical outcome in neuroendocrine tumors of the appendix: a retrospective clinical pathologic analysis of 138 cases.},
  author={Marco Volante and Lorenzo Daniele and Sofia Asioli and Paola Cassoni and Alberto Comino and Sergio Coverlizza and Paolo De Giuli and Cristina Fava and Claudia Manini and Alfredo Berruti and Mauro Papotti},
  journal={The American journal of surgical pathology},
  year={2013},
  volume={37 4},
  pages={606-12}
}
Appendiceal neuroendocrine neoplasms (NENs) are rare and usually incidentally discovered. Most cases are clinically indolent, although the rare aggressive ones are poorly predictable. The aim of this study was to test the applicability and prognostic significance of the new World Health Organization (WHO) classification and to test the several pathologic features and TNM staging systems (American Joint Committee on Cancer and European Neuroendocrine Tumor Society) in these tumors. A multi… CONTINUE READING
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