Tumor spectrum analysis in p53-mutant mice.

  title={Tumor spectrum analysis in p53-mutant mice.},
  author={Tyler E. Jacks and Lee Remington and Bart O. Williams and Earlene M. Schmitt and Sarel Halachmi and Roderick Terry Bronson and Robert A Weinberg},
  journal={Current biology : CB},
  volume={4 1},
BACKGROUND The p53 tumor suppressor gene is mutated in a large percentage of human malignancies, including tumors of the colon, breast, lung and brain. Individuals who inherit one mutant allele of p53 are susceptible to a wide range of tumor types. The gene encodes a transcriptional regulator that may function in the cellular response to DNA damage. The construction of mouse strains carrying germline mutations of p53 facilitates analysis of the function of p53 in normal cells and tumorigenesis… CONTINUE READING
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