Tumor-specific silencing of COPZ2 gene encoding coatomer protein complex subunit ζ 2 renders tumor cells dependent on its paralogous gene COPZ1.

@article{Shtutman2011TumorspecificSO,
  title={Tumor-specific silencing of COPZ2 gene encoding coatomer protein complex subunit ζ 2 renders tumor cells dependent on its paralogous gene COPZ1.},
  author={Michael Shtutman and Mirza Ashad Baig and Elina Levina and Gregory J. Hurteau and Chang-Uk Lim and Eugenia V. Broude and Mikhail E. Nikiforov and Timothy T. Harkins and C. Steven Carmack and Ye Ding and Felix Wieland and Ralph Buttyan and Igor B. Roninson},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2011},
  volume={108 30},
  pages={12449-54}
}
Anticancer drugs are effective against tumors that depend on the molecular target of the drug. Known targets of cytotoxic anticancer drugs are involved in cell proliferation; drugs acting on such targets are ineffective against nonproliferating tumor cells, survival of which leads to eventual therapy failure. Function-based genomic screening identified the… CONTINUE READING