Tumor-specific pH-responsive peptide-modified pH-sensitive liposomes containing doxorubicin for enhancing glioma targeting and anti-tumor activity.

@article{Zhao2016TumorspecificPP,
  title={Tumor-specific pH-responsive peptide-modified pH-sensitive liposomes containing doxorubicin for enhancing glioma targeting and anti-tumor activity.},
  author={Yang Zhao and Wei Ren and Ting Zhong and Shuang Zhang and Dan ” Huang and Yang Guo and Xin Yao and Chao Wang and Wei-Qiang Zhang and Xuan Zhang and Qiang Zhang},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2016},
  volume={222},
  pages={
          56-66
        }
}
The pH environment in gliomas is acidic. Therefore, in the present research, we selected our previously reported tumor-specific pH-responsive peptide H7K(R2)2 as a targeting ligand, which could respond to the acidic pH environment in gliomas, possessing CPP characteristics. The pH-sensitive liposomes were selected as carriers which could also respond to the acidic pH environment in gliomas triggering encapsulated drug release from these pH-sensitive liposomes. The H7K(R2)2-modified pH-sensitive… CONTINUE READING
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