Tumor-specific microsatellite instability: do distinct mechanisms underlie the MSI-L and EMAST phenotypes?

@article{Hile2013TumorspecificMI,
  title={Tumor-specific microsatellite instability: do distinct mechanisms underlie the MSI-L and EMAST phenotypes?},
  author={Suzanne E. Hile and Samion Shabashev and K. A. Eckert},
  journal={Mutation research},
  year={2013},
  volume={743-744},
  pages={67-77}
}
Microsatellite DNA sequences display allele length alterations or microsatellite instability (MSI) in tumor tissues, and MSI is used diagnostically for tumor detection and classification. We discuss the known types of tumor-specific MSI patterns and the relevant mechanisms underlying each pattern. Mutation rates of individual microsatellites vary greatly, and the intrinsic DNA features of motif size, sequence, and length contribute to this variation. MSI is used for detecting mismatch repair… CONTINUE READING
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