Tumor-specific methylation in bronchial lavage for the early detection of non-small-cell lung cancer.

@article{Kim2004TumorspecificMI,
  title={Tumor-specific methylation in bronchial lavage for the early detection of non-small-cell lung cancer.},
  author={Hojoong Kim and Young Mi Kwon and Jin Seuk Kim and Haengbyoung Lee and Jung-Ho Park and Young Mog Shim and Joungho Han and Joobae Park and Duk-Hwan Kim},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2004},
  volume={22 12},
  pages={2363-70}
}
PURPOSE The aim of this study was to identify tumor-specific methylation in bronchial lavage for the early detection of non-small-cell lung cancer (NSCLC) by differentiating the age-related methylation from the tumor-specific methylation in NSCLC. PATIENTS AND METHODS Eighty-five NSCLC patients and 127 cancer-free subjects participated in this study. Aberrant methylation at the promoters of the p16, Ras association domain family 1A (RASSF1A), fragile histidine triad (FHIT), H-cadherin, and… CONTINUE READING

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