Tumor-specific gene expression in carcinoembryonic antigen--producing gastric cancer cells using adenovirus vectors.

@article{Lan1996TumorspecificGE,
  title={Tumor-specific gene expression in carcinoembryonic antigen--producing gastric cancer cells using adenovirus vectors.},
  author={K H Lan and Fumihiko Kanai and Yasushi Shiratori and Satoshi Okabe and Yoko Yoshida and Hiroaki Wakimoto and Hirofumi Hamada and Takemi Tanaka and Makoto Ohashi and Masao Omata},
  journal={Gastroenterology},
  year={1996},
  volume={111 5},
  pages={1241-51}
}
BACKGROUND & AIMS An increase of carcinoembryonic antigen (CEA) expression is noted in about 40% of patients with gastric cancer. Adenovirus-mediated gene therapy using the CEA promoter was investigated as a way to specifically target human CEA-producing gastric tumors. METHODS Recombinant adenovirus vectors carrying a CEA promoter linked to the lacZ gene (AdCEA lacZ) or the cytosine deaminase gene (AdCEA-CD) were constructed. After infection with these vectors, CEA-producing (MKN45 and MKN28… CONTINUE READING

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