Tumor-specific delivery of doxorubicin through conjugation of pH-responsive peptide for overcoming drug resistance in cancer.

@article{Feng2017TumorspecificDO,
  title={Tumor-specific delivery of doxorubicin through conjugation of pH-responsive peptide for overcoming drug resistance in cancer.},
  author={Chunlai Feng and Mengjie Rui and Haijun Shen and Yuanrong Xin and Jie Zhang and Jun Li and Lixiang Yue and Wenlong Lai and Ximing Xu},
  journal={International journal of pharmaceutics},
  year={2017},
  volume={528 1-2},
  pages={322-333}
}
The major obstacles opposed to doxorubicin (Dox) based chemotherapy are the induction of drug resistance, together with non-specific toxicities for healthy cells. In this study, we prepared a peptide-Dox conjugate aimed at offering Dox molecules a tumor-specific functionality and improving the therapeutic effects of Dox against resistant tumor cells. A slightly acidic pH-sensitive peptide (SAPSP) with high selectivity for cancer cells was attached to Dox to obtain SAPSP-Dox prodrug. The… CONTINUE READING

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