Tumor-specific cytotoxic T cell clones from patients with breast and pancreatic adenocarcinoma recognize EBV-immortalized B cells transfected with polymorphic epithelial mucin complementary DNA.

@article{Jerome1993TumorspecificCT,
  title={Tumor-specific cytotoxic T cell clones from patients with breast and pancreatic adenocarcinoma recognize EBV-immortalized B cells transfected with polymorphic epithelial mucin complementary DNA.},
  author={Keith R. Jerome and Nieves Dom{\'e}nech and Olivera Olja J Finn},
  journal={Journal of immunology},
  year={1993},
  volume={151 3},
  pages={1654-62}
}
Human breast and pancreatic adenocarcinomas are tumors of ductal epithelial cell origin and as such produce and express on their surface polymorphic epithelial cell mucin encoded by the MUC 1 gene. We have previously reported that tumor-specific cytotoxic T cells derived from patients bearing such tumors recognize specific epitopes on the mucin polypeptide core. This recognition was not MHC-restricted because of the highly repetitive sequence of the polypeptide core, which allows simultaneous… CONTINUE READING

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Mentioned Connections BETA
MucinsGene product expressed in tissueEpithelial Cells
Human breast and pancreatic adenocarcinomas are tumors of ductal epithelial cell origin and as such produce and express on their surface polymorphic epithelial cell mucin encoded by the MUC 1 gene .
Human breast and pancreatic adenocarcinomas are tumors of ductal epithelial cell origin and as such produce and express on their surface polymorphic epithelial cell mucin encoded by the MUC 1 gene .
Neoplastic CellIs abnormal cell of diseaseNeoplasms
Those studies were performed with limited numbers of tumor cells or allogeneic tumor cell lines .
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