Tumor specific conversion of a pyrimidine antimetabolite.


In order to explain the high differences of activity of 5'-dFUR and FUdR in the 4 tumor lines the conversion rate of the 2 nucleosides to the cytotoxic metabolite 5-FU was measured and compared with the conversion rate of uridine to uracil in tumor and liver homogenates. High activity of pyrimidine nucleoside phosphorylase was found in 5'-dFUR-sensitive… (More)


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