Tumor-specific antigens and tumor-specific mutant proteins in mouse and man.


The modern era of cancer immunology began with the discovery that inbred mice could be immunized against cancers that had been induced by chemical carcinogens such as the polycyclic hydrocarbon methylcholanthrene (MCA) [1-4]. Particularly, studies of Prehn and Main in 1957 made it highly unlikely that the antigens on the cancers were also widely expressed… (More)