Tumor-specific T cells in human Merkel cell carcinomas: a possible role for Tregs and T cell exhaustion in reducing T cell responses

@inproceedings{Dowlatshahi2013TumorspecificTC,
  title={Tumor-specific T cells in human Merkel cell carcinomas: a possible role for Tregs and T cell exhaustion in reducing T cell responses},
  author={Mitra Dowlatshahi and Victor Huang and Ahmed Gehad and Ying Jiang and Adam W Calarese and Jessica E. Teague and Andrew A Dorosario and Jingwei Cheng and Paul Nghiem and Carl F. Schanbacher and Manisha Thakuria and Chrysalyne Delling Schmults and Linda C. Wang and Rachael A Clark},
  booktitle={The Journal of investigative dermatology},
  year={2013}
}
Merkel cell carcinomas (MCCs) are rare but highly malignant skin cancers associated with a recently described polyomavirus. MCC tumors were infiltrated by T cells, including effector, central memory, and regulatory T cells. Infiltrating T cells showed markedly reduced activation as evidenced by reduced expression of CD69 and CD25. Treatment of MCC tumors in vitro with IL-2 and IL-15 led to T-cell activation, proliferation, enhanced cytokine production, and loss of viable tumor cells from… CONTINUE READING

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