Tumor-specific RNAi targeting eIF4E suppresses tumor growth, induces apoptosis and enhances cisplatin cytotoxicity in human breast carcinoma cells

@article{Dong2008TumorspecificRT,
  title={Tumor-specific RNAi targeting eIF4E suppresses tumor growth, induces apoptosis and enhances cisplatin cytotoxicity in human breast carcinoma cells},
  author={Ke Dong and Rui Wang and Xi Wang and Fang Lin and Jian-jun Shen and Ping Gao and Huizhong Zhang},
  journal={Breast Cancer Research and Treatment},
  year={2008},
  volume={113},
  pages={443-456}
}
Background Eukaryotic initiation factor eIF4E, an important regulator of translation, plays a crucial role in the malignant transformation, progression and chemoresistance of many human solid tumors. The overexpression of this gene has been found in a variety of human malignancies including breast carcinoma. In the present study, we attempted to explore the possibility of eIF4E as a therapeutic target for the treatment of human breast carcinoma using breast carcinoma cell line (MCF-7… CONTINUE READING
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