Tumor-specific PAX3-FKHR transcription factor, but not PAX3, activates the platelet-derived growth factor alpha receptor.

@article{Epstein1998TumorspecificPT,
  title={Tumor-specific PAX3-FKHR transcription factor, but not PAX3, activates the platelet-derived growth factor alpha receptor.},
  author={Jonathan A. Epstein and Bongkeun Song and M. El Lakkis and Cun-yu Wang},
  journal={Molecular and cellular biology},
  year={1998},
  volume={18 7},
  pages={
          4118-30
        }
}
The t(2;13) chromosomal translocation occurs at a high frequency in alveolar rhabdomyosarcoma, a common pediatric tumor of muscle. This translocation results in the production of a chimeric fusion protein derived from two developmentally regulated transcription factors, PAX3 and FKHR. The two DNA binding modules, the paired domain and the homeodomain, of PAX3 are fused in frame to the transactivation domain of FKHR. Previously, tumor-specific PAX3-FKHR has been shown to bind to DNA sequences… CONTINUE READING
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