Tumor-selective action of HDAC inhibitors involves TRAIL induction in acute myeloid leukemia cells

  title={Tumor-selective action of HDAC inhibitors involves TRAIL induction in acute myeloid leukemia cells},
  author={Angela Nebbioso and Nicole A Clarke and Emilie Voltz and Emmanuelle Germain and Concetta Ambrosino and Paola Bontempo and Rosana {\'A}lvarez and Ettore Mariano Schiavone and Felicetto Ferrara and Francesco Bresciani and Alessandro Weisz and Angel R. de Lera and Hinrich Gronemeyer and Lucia Altucci},
  journal={Nature Medicine},
Chromatin is a dynamic macromolecular structure epigenetically modified to regulate specific gene expression. Altered chromatin function can lead to aberrant expression of growth regulators and may, ultimately, cause cancer. That many human diseases have epigenetic etiology has stimulated the development of 'epigenetic' therapies. Inhibitors of histone deacetylases (HDACIs) induce proliferation arrest, maturation and apoptosis of cancer cells, but not normal cells, in vitro and in vivo, and are… CONTINUE READING
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Gene expression profiling of multiple histone deacetylase ( HDAC ) inhibitors : defining a common gene set produced by HDAC inhibition in T 24 and MDA carcinoma cell lines

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  • Mol . Cancer Ther .
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