Tumor response and estrogen suppression in breast cancer patients treated with aromatase inhibitors.

@article{Bajetta2000TumorRA,
  title={Tumor response and estrogen suppression in breast cancer patients treated with aromatase inhibitors.},
  author={Emilio Bajetta and Nicoletta Zilembo and Ettore Bichisao and Antonella Martinetti and Roberto Buzzoni and Paola Pozzi and Paolo Bidoli and Leonardo Ferrari and Luigi Celio},
  journal={Annals of oncology : official journal of the European Society for Medical Oncology},
  year={2000},
  volume={11 8},
  pages={1017-22}
}
BACKGROUND The rationale for the hormonal treatment of breast cancer (BC) is based on depriving tumor cells of estrogenic stimulation. Aromatase inhibitors (Als) block the conversion of peripheral tissue androgens to estrogens with different levels of potency. In an attempt to investigate the relationship between tumor response and estrogen suppression, we reviewed the hormonal and clinical data of two previous studies with formestane (250 and 500 mg i.m. fortnightly) in advanced BC patients… CONTINUE READING

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