Tumor regression grading after preoperative chemoradiotherapy for locally advanced rectal carcinoma revisited: updated results of the CAO/ARO/AIO-94 trial.

@article{Fokas2014TumorRG,
  title={Tumor regression grading after preoperative chemoradiotherapy for locally advanced rectal carcinoma revisited: updated results of the CAO/ARO/AIO-94 trial.},
  author={Emmanouil Fokas and Torsten Liersch and Rainer Fietkau and Werner Hohenberger and Tim Bei\ssbarth and Clemens Friedrich Hess and Heinz Becker and Michael B. Ghadimi and Karl Mrak and Susanne Merkel and Hans-Rudolf Raab and Rolf Sauer and Christian Wittekind and Claus Michael R{\"o}del},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2014},
  volume={32 15},
  pages={1554-62}
}
PURPOSE We previously described the prognostic impact of tumor regression grading (TRG) on the outcome of patients with rectal carcinoma treated with preoperative chemoradiotherapy (CRT) in the CAO/ARO/AIO-94 trial. Here we report long-term results after a median follow-up of 132 months. PATIENTS AND METHODS TRG after preoperative CRT was determined in 386 surgical specimens by the amount of viable tumor cells versus fibrosis, ranging from TRG 4 (no viable tumor cells) to TRG 0 (no signs of… CONTINUE READING
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