Tumor regression after systemic administration of a novel tumor-targeted gene delivery system carrying a therapeutic plasmid DNA.

Abstract

The possibility of using genes as medicines to treat cancer is limited by the lack of safe and efficacious delivery systems able to deliver therapeutic genes selectively to tumors by intravenous administration. We investigate if the conjugation of the polypropylenimine dendrimer to transferrin, whose receptors are overexpressed on numerous cancers, could… (More)
DOI: 10.1016/j.jconrel.2009.11.015

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Cite this paper

@article{Koppu2010TumorRA, title={Tumor regression after systemic administration of a novel tumor-targeted gene delivery system carrying a therapeutic plasmid DNA.}, author={Swati Koppu and Yew Jinn Oh and RuAngelie Edrada-Ebel and David R. Blatchford and Laurence Tetley and Rothwelle J. Tate and Christine Duf{\`e}s}, journal={Journal of controlled release : official journal of the Controlled Release Society}, year={2010}, volume={143 2}, pages={215-21} }