Tumor-recruited neutrophils and neutrophil TIMP-free MMP-9 regulate coordinately the levels of tumor angiogenesis and efficiency of malignant cell intravasation.

@article{Bekes2011TumorrecruitedNA,
  title={Tumor-recruited neutrophils and neutrophil TIMP-free MMP-9 regulate coordinately the levels of tumor angiogenesis and efficiency of malignant cell intravasation.},
  author={Erin M Bekes and Bernhard Schweighofer and Tatyana Kupriyanova and E. E. Zajac and Veronica C. Ardi and James P. Quigley and Elena I. Deryugina},
  journal={The American journal of pathology},
  year={2011},
  volume={179 3},
  pages={1455-70}
}
Tumor-associated neutrophils contribute to neovascularization by supplying matrix metalloproteinase-9 (MMP-9), a protease that has been genetically and biochemically linked to induction of angiogenesis. Specific roles of inflammatory neutrophils and their distinct proMMP-9 in the coordinate regulation of tumor angiogenesis and tumor cell dissemination, however, have not been addressed. We demonstrate that the primary tumors formed by highly disseminating variants of human fibrosarcoma and… CONTINUE READING

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