Tumor prostaglandin levels correlate with edema around supratentorial meningiomas.

  title={Tumor prostaglandin levels correlate with edema around supratentorial meningiomas.},
  author={Shlomi Constantini and Jeremy Tamir and Moshe John Gomori and Esther Shohami},
  volume={33 2},
  pages={204-10; discussion 211}
The pathophysiological mechanisms to explain peritumoral edema have not been clarified. Multiple aspects of brain edema secondary to supratentorial meningiomas were prospectively investigated in a group of 29 patients who underwent surgery consecutively. Sixty-nine tumor samples were analyzed for prostanoid levels. Levels of 6-keto-PGF1 alpha, the stable metabolite of prostacycline, were found to correlate well with the extent of edema (r = 0.51, P < 0.01). The ratio, 6-keto-PGF1 alpha x PGE2… CONTINUE READING
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