Tumor promotion by phorbol esters in skin: evidence for a memory effect.

@article{Frstenberger1983TumorPB,
  title={Tumor promotion by phorbol esters in skin: evidence for a memory effect.},
  author={Gerhard F{\"u}rstenberger and Bernhard Sorg and Frederick W. Marks},
  journal={Science},
  year={1983},
  volume={220 4592},
  pages={
          89-91
        }
}
By means of a two-stage promotion protocol in mouse epidermis with 12-O-tetradecanoylphorbol-13-acetate as first-stage promoter and 12-O-retinoylphorbol-13-acetate as second-stage promoter, the effects of the former that are critical and obligatory for tumor promotion were shown to be irreversible in nature for at least 8 weeks. The reversibility of tumor promotion was related to the second stage of promotion, reflecting the reversibility of epidermal hyperplasia induced by 12-O… CONTINUE READING
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