Tumor promotion by caspase-resistant retinoblastoma protein.

@article{Borges2005TumorPB,
  title={Tumor promotion by caspase-resistant retinoblastoma protein.},
  author={Helena Lobo Borges and Jeff Bird and Katherine Wasson and Robert Cardiff and Nissi M. Varki and Lars Eckmann and Jean Y. J. Wang},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2005},
  volume={102 43},
  pages={
          15587-92
        }
}
The retinoblastoma (RB) protein regulates cell proliferation and cell death. RB is cleaved by caspase during apoptosis. A mutation of the caspase-cleavage site in the RB C terminus has been made in the mouse Rb-1 locus; the resulting Rb-MI mice are resistant to endotoxin-induced apoptosis in the intestine. The Rb-MI mice do not exhibit increased tumor incidence, because the MI mutation does not disrupt the Rb tumor suppressor function. In this study, we show that Rb-MI can promote the formation… CONTINUE READING

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