Tumor-promoting phorbol esters induce angiogenesis in vitro

  title={Tumor-promoting phorbol esters induce angiogenesis in vitro},
  author={Roberto Montesano and Lelio Orci},
A crucial event during angiogenesis is the invasion of the perivascular extracellular matrix by sprouting endothelial cells. To investigate the possible role of proteases in endothelial cell invasiveness in vitro, bovine microvascular endothelial cells (BMEC) grown on collagen gels were treated with phorbol myristate acetate (PMA), a tumor promoter that markedly increases their production of collagenase and plasminogen activator. Whereas control BMEC were confined to the surface of the gels… CONTINUE READING


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