Tumor-promoting phorbol diesters mediate phosphorylation of the epidermal growth factor receptor.

@article{Davis1984TumorpromotingPD,
  title={Tumor-promoting phorbol diesters mediate phosphorylation of the epidermal growth factor receptor.},
  author={Roger J Davis and M. Czech},
  journal={The Journal of biological chemistry},
  year={1984},
  volume={259 13},
  pages={8545-9}
}
4 beta-Phorbol 12 beta-myristate 13 alpha-acetate (PMA) markedly inhibited the binding of low concentrations (less than 10(-9 m) of 125I-epidermal growth factor (EGF) to A431 human epidermoid carcinoma cells. However, very little change in the binding of 125-I-EGF at high concentrations (greater than 10(-8) M) was observed in response to PMA. Affinity labeling of the 170,000-dalton EGF receptor with 125I-EGF and disuccinimidyl suberate was also decreased by the tumor promoter at low, but not… CONTINUE READING

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