Tumor-promoting functions of transforming growth factor-β in progression of cancer

@inproceedings{Miyazono2012TumorpromotingFO,
  title={Tumor-promoting functions of transforming growth factor-β in progression of cancer},
  author={Kohei Miyazono and Shogo Ehata and Daizo Koinuma},
  booktitle={Upsala journal of medical sciences},
  year={2012}
}
Transforming growth factor-β (TGF-β) elicits both tumor-suppressive and tumor-promoting functions during cancer progression. Here, we describe the tumor-promoting functions of TGF-β and how these functions play a role in cancer progression. Normal epithelial cells undergo epithelial-mesenchymal transition (EMT) through the action of TGF-β, while treatment with TGF-β and fibroblast growth factor (FGF)-2 results in transdifferentiation into activated fibroblastic cells that are highly migratory… CONTINUE READING
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