Tumor-promoting Activity of Staurosporine , a Protein Kinase Inhibitor on Mouse Skin 1

Abstract

Staurosporine, which is a potent inhibitor of protein kinases, such as protein kinase C, inhibited both inductions of adhesion of human promyelocytic leukemia cells (50% effective dose = 9.0 n.\t) and EpsteinBarr virus early antigen in Raji cells (50% effective dose = 3.4 nivi) by teleocidin. However, Staurosporine induced irritation on mouse ear and… (More)

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