Tumor promoters inhibit spontaneous differentiation of Friend erythroleukemia cells in culture.

@article{Rovera1977TumorPI,
  title={Tumor promoters inhibit spontaneous differentiation of Friend erythroleukemia cells in culture.},
  author={Giovanni Giacomo Rovera and Thomas G. O'Brien and L. Kaili Diamond},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1977},
  volume={74 7},
  pages={2894-8}
}
Clones of Friend erythroleukemia cells, characterized by the presence of 40-70% benzidine-positive cells synthesizing hemoglobin in the absence of inducing drugs, were treated with several phorbol diesters with a known range of tumor-promoting activity on mouse skin. Good correlation was found between the reported tumor-promoting activity of a particular phorbol diester and its ability to inhibit spontaneous erythroid differentiation in culture. The inhibition of differentiation by 12-O… CONTINUE READING

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