Tumor promoters cause a rapid and reversible inhibition of the formation and maintenance of electrical cell coupling in culture.

@article{Enomoto1981TumorPC,
  title={Tumor promoters cause a rapid and reversible inhibition of the formation and maintenance of electrical cell coupling in culture.},
  author={Tomoo Enomoto and Yasuharu Sasaki and Yoshiki Shiba and Yoshinobu Kanno and Hiroshi Yamasaki},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1981},
  volume={78 9},
  pages={5628-32}
}
The effect of tumor promoters on electrical coupling between human FL cells was investigated with a microelectrode technique. When a low concentration (100 ng/ml) of 12-O-tetradecanoylphorbol 13-acetate (TPA) was added to culture medium, only 6% of the cells showed electrical coupling after 5 hr, whereas in control medium more than 90% of the cells were coupled. In the presence of TPA, cell coupling remained suppressed for at least another 19 hr. When TPA was washed out from the culture medium… CONTINUE READING
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