Tumor promoters as inhibitors of apoptosis in rat hepatocytes.

  title={Tumor promoters as inhibitors of apoptosis in rat hepatocytes.},
  author={Dieter Schrenk and H J Schmitz and Susanne Bohnenberger and Brent Wagner and William Woerner},
  journal={Toxicology letters},
  volume={149 1-3},
Multistage carcinogenesis in rat liver is widely used as an experimental model for the study of the critical events in tumor promotion. After an initial treatment with a genotoxic liver carcinogen ('initiation'), subsequent application of certain non-genotoxic agents can lead to the clonal expansion of putative preneoplastic cells ('promotion'). Obviously, the expansion of these clones is correlated with an increased occurrence of benign and malignant liver tumors at later time points. Since… CONTINUE READING