Tumor promoter stimulation of phosphatidylcholine turnover in HeLa cells.

  title={Tumor promoter stimulation of phosphatidylcholine turnover in HeLa cells.},
  author={Graeme R. Guy and Andrew W. Murray},
  journal={Cancer research},
  volume={42 5},
Incubation of HeLa cells for 24 hr with [3H]choline resulted in extensive labeling of the phosphorylcholine and phosphatidylcholine pools. 12-O-Tetradecanoylphorbol-13-acetate (TPA), other phorbol ester tumor promoters, and mezerein stimulated the release of [3H]choline and [3H]phosphorylcholine from such prelabeled cells. The release was accompanied by decreased radioactivity in the phosphorylcholine pool, raising the possibility that the released materials were derived by leakage from this… CONTINUE READING
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