Tumor promoter induces sister chromatid exchanges: relevance to mechanisms of carcinogenesis.

  title={Tumor promoter induces sister chromatid exchanges: relevance to mechanisms of carcinogenesis.},
  author={Anne R Kinsella and Miroslav Radman},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={75 12},
12-O-Tetradecanoylphorbol 13-acetate (TPA), a powerful tumor promoter, is shown to induce sister chromatid exchanges (SCEs), whereas the nonpromoting derivative 4-O-methyl-TPA does not. Inhibitors of tumor promotion--antipain, leupeptin, and fluocinolone acetonide--inhibit formation of such TPA-induced SCEs. TPA is a unique agent in its induction of SCEs in the absence of DNA damage, chromosome aberrations, mutagenesis, or significant toxicity. Because TPA is known to induce several gene… CONTINUE READING


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Publications referenced by this paper.

( 977 ) Mutation Res

G. R. Lankas, C. S. Baxter, R. T. Christian
Cancer Res . • 1977

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