Tumor progression locus-2 is a critical regulator of pancreatic and lung inflammation during acute pancreatitis.

@article{Acker2007TumorPL,
  title={Tumor progression locus-2 is a critical regulator of pancreatic and lung inflammation during acute pancreatitis.},
  author={Gijs J. D. van Acker and George Perides and Eric R. Weiss and Santasabuj Das and Philip N Tsichlis and Michael L. Steer},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 30},
  pages={22140-9}
}
Pancreatic and lung inflammation during acute pancreatitis is a poorly understood, but clinically important, phenomenon. The proto-oncogene Tpl2 (tumor progression locus-2) has recently been shown to have important immunomodulatory effects on some inflammatory processes, but its importance to pancreatitis has not been previously examined. Our studies were designed to (a) define the effects of Tpl2 on pancreatic and lung inflammation during pancreatitis and (b) identify mechanisms and cell types… CONTINUE READING
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