Tumor progression: the effects of thrombospondin-1 and -2.

@article{Lawler2004TumorPT,
  title={Tumor progression: the effects of thrombospondin-1 and -2.},
  author={Jack W Lawler and Michael Detmar},
  journal={The international journal of biochemistry & cell biology},
  year={2004},
  volume={36 6},
  pages={1038-45}
}
The thrombospondins (TSPs) are a family of proteins that regulate tissue genesis and remodeling. In many tumors, down-regulation of TSPs accompanies activation of oncogenes or inactivation of tumor suppresser genes and appears to be a prerequisite for the aquisition of a pro-angiogenic phenotype. The normal suppression of angiogenesis by TSP-1 and -2… CONTINUE READING