Tumor prognostic factors and the challenge of developing predictive factors.

Abstract

Histopathologic classification has been widely used to type and grade primary brain tumors. However, the diverse behavior of primary brain tumors has made prognostic determinations based purely on clinical and histopathologic variables difficult. Recent advances in the molecular genetics of brain tumors have helped to explain the witnessed heterogeneity regarding response to treatment, time to progression, and overall survival. Additionally, there has been interest in identifying predictive factors to help direct patients to therapeutic interventions specific to their tumor and patient biology. Further identification of both prognostic and predictive biomarkers will make possible better patient stratification and individualization of treatment.

DOI: 10.1007/s11912-012-0283-3

1 Figure or Table

Statistics

0500100020162017
Citations per Year

140 Citations

Semantic Scholar estimates that this publication has 140 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Holliday2013TumorPF, title={Tumor prognostic factors and the challenge of developing predictive factors.}, author={Emma B Holliday and Erik P. Sulman}, journal={Current oncology reports}, year={2013}, volume={15 1}, pages={33-46} }