Tumor-penetrating peptide enhances transcytosis of silicasome-based chemotherapy for pancreatic cancer

@article{Liu2017TumorpenetratingPE,
  title={Tumor-penetrating peptide enhances transcytosis of silicasome-based chemotherapy for pancreatic cancer},
  author={X. Liu and Paulina Lin and Ian Perrett and Joshua Lin and Y. Liao and C. Chang and Jinhong Jiang and N. Wu and T. Donahue and Z. Wainberg and A. Nel and Huan Meng},
  journal={Journal of Clinical Investigation},
  year={2017},
  volume={127},
  pages={2007–2018}
}
Pancreatic ductal adenocarcinoma (PDAC) is almost uniformly fatal; however, some improvement in overall survival has been achieved with the introduction of nanocarriers that deliver irinotecan or paclitaxel. Although it is generally assumed that nanocarriers rely principally on abnormal leaky vasculature for tumor access, a transcytosis transport pathway that is regulated by neuropilin-1 (NRP-1) has recently been reported. NRP-1–mediated transport can be triggered by the cyclic tumor… Expand
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