Tumor necrosis factor. Characterization at the molecular, cellular and in vivo level.

@article{Fiers1991TumorNF,
  title={Tumor necrosis factor. Characterization at the molecular, cellular and in vivo level.},
  author={Walter Fiers},
  journal={FEBS letters},
  year={1991},
  volume={285 2},
  pages={199-212}
}
TNF was originally characterized as an antitumor agent and a factor cytotoxic for many malignant cells. It is now clear that it plays an important role in the defense against viral, bacterial and parasitic infections, - and in (auto-)immune responses. Natural induction of TNF is protective, but its overproduction may be detrimental and even lethal to the host. The structure of TNF and its interaction with the two types of cellular receptor are becoming better understood. TNF elicits a variety… CONTINUE READING

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