Tumor necrosis factor-related apoptosis-inducing ligand promotes migration of human bone marrow multipotent stromal cells.

@article{Secchiero2008TumorNF,
  title={Tumor necrosis factor-related apoptosis-inducing ligand promotes migration of human bone marrow multipotent stromal cells.},
  author={Paola Secchiero and Elisabetta Melloni and Federica Corallini and Antonio Paolo Beltrami and Francesco Alviano and Daniela Milani and Federica D'aurizio and Maria Grazia di Iasio and Daniela Cesselli and Gian Paolo Bagnara and Giorgio Zauli},
  journal={Stem cells},
  year={2008},
  volume={26 11},
  pages={2955-63}
}
Adult multipotent stromal cells (MSCs), also known as mesenchymal stem cells, represent an important source of cells for the repair of a number of damaged tissues. Both bone marrow (BM)-derived and amniotic MSCs expressed detectable surface levels of two (tumor necrosis factor-related apoptosis-inducing ligand receptor 2 [TRAIL-R2] and TRAIL-R4) of four transmembrane TRAIL receptors. Although the best-characterized activity of TRAIL-R2 is the transduction of apoptotic signals, neither… CONTINUE READING

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