Tumor necrosis factor-related apoptosis-inducing ligand can induce apoptosis in subsets of premalignant cells.

@article{Lu2004TumorNF,
  title={Tumor necrosis factor-related apoptosis-inducing ligand can induce apoptosis in subsets of premalignant cells.},
  author={Xiaojun Lu and Jack L. Arbiser and James L. West and Marloes Hoedt-Miller and Alison Sheridan and Baskaran Govindarajan and Julie Wright Harral and David M. Rodman and Brian Fouty},
  journal={The American journal of pathology},
  year={2004},
  volume={165 5},
  pages={1613-20}
}
During the transformation from a normal to a malignant cell, several mutations are required to bypass the pathways responsible for controlling proliferation. Premalignant cells have acquired some, but not all of these mutations and consequently have not yet attained a malignant phenotype characterized by tumor formation in vivo. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) can induce apoptosis in malignant cells while sparing normal ones and is currently being considered as… CONTINUE READING