Tumor necrosis factor receptors 1 and 2 differentially regulate survival, cardiac dysfunction, and remodeling in transgenic mice with tumor necrosis factor-alpha-induced cardiomyopathy.

@article{Higuchi2004TumorNF,
  title={Tumor necrosis factor receptors 1 and 2 differentially regulate survival, cardiac dysfunction, and remodeling in transgenic mice with tumor necrosis factor-alpha-induced cardiomyopathy.},
  author={Yoshihiro Higuchi and Charles F McTiernan and Carole Bengston Frye and Brian S. McGowan and Tung O. Chan and Arthur M Feldman},
  journal={Circulation},
  year={2004},
  volume={109 15},
  pages={1892-7}
}
BACKGROUND Tumor necrosis factor (TNF)-alpha plays a pathophysiological role in heart failure. Although both TNF receptor 1 (TNFR1) and 2 (TNFR2) are present in the heart, comparatively little is known about the role of TNFR2. METHODS AND RESULTS We bred TNFR1-knockout (KO) or TNFR2KO mice to transgenic (TG) mice with cardiac-specific overexpression of TNF-alpha and analyzed resultant progeny. Six groups of male and female mice were studied: wild type (WT) with wild receptors (WT/W), TG with… CONTINUE READING
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