Tumor necrosis factor receptor-associated factor 5 is an essential mediator of ischemic brain infarction.

@article{Wang2013TumorNF,
  title={Tumor necrosis factor receptor-associated factor 5 is an essential mediator of ischemic brain infarction.},
  author={Lang Lang Wang and Yanyun Lu and Hongjing Guan and Dingsheng Jiang and Yu Guan and Xin Zhang and Hiroyasu Nakano and Yan Zhou and Yan Zhang and Li Yang and Hongliang Li},
  journal={Journal of neurochemistry},
  year={2013},
  volume={126 3},
  pages={400-14}
}
Tumor necrosis factor receptor-associated factor 5 (TRAF5) is an adaptor protein of the tumor necrosis factor (TNF) receptor superfamily and the interleukin-1 receptor/Toll-like receptor superfamily and plays important roles in regulating multiple signaling pathways. This study was conducted to investigate the role of TRAF5 in the context of brain ischemia/reperfusion (I/R) injury. Transient occlusion of the middle cerebral artery was performed on TRAF5 knockout mice (KO), neuron-specific TRAF5… CONTINUE READING