Tumor necrosis factor receptor-associated death domain mediated neuronal death contributes to the glial activation and subsequent neuroinflammation in Japanese encephalitis.

@article{Swarup2008TumorNF,
  title={Tumor necrosis factor receptor-associated death domain mediated neuronal death contributes to the glial activation and subsequent neuroinflammation in Japanese encephalitis.},
  author={Vivek Swarup and Joydeep Ghosh and Sulagna Das and Anirban Basu},
  journal={Neurochemistry international},
  year={2008},
  volume={52 7},
  pages={1310-21}
}
While a number of studies have documented the importance of microglia in central nervous system (CNS) response to injury, infection and in disease state, little is known regarding how the neuronal death initiates the cascades of secondary neuroinflammation. We have exploited an experimental model of Japanese encephalitis to better understand how neuronal death following viral infection initiates microglial activation following Japanese encephalitis virus infection. We have earlier shown that… CONTINUE READING
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