Tumor necrosis factor plays an essential role in determining hypersensitivity pneumonitis in a mouse model.

@article{Denis1991TumorNF,
  title={Tumor necrosis factor plays an essential role in determining hypersensitivity pneumonitis in a mouse model.},
  author={Michel Denis and Yvon Cormier and Mathilde Fournier and Jean-Claude Tardif and Michel Laviolette},
  journal={American journal of respiratory cell and molecular biology},
  year={1991},
  volume={5 5},
  pages={477-83}
}
We examined the importance of the cytokine tumor necrosis factor-alpha (TNF-alpha) in a mouse model of hypersensitivity pneumonitis (HP). Mice of the C57BL/6 strain were instilled intranasally 3 days/wk for 3 wk with 150 micrograms of the actinomycete Faenia rectivirgula (Micropolyspora faeni) to induce HP as a model of farmer's lung. This experimental model was associated with a progressive inflammation in the lungs of challenged mice, seen histologically as cellular infiltrates of large… CONTINUE READING