Tumor necrosis factor is increased in the spinal cord of an animal model of motor neuron degeneration.

@article{Ghezzi1998TumorNF,
  title={Tumor necrosis factor is increased in the spinal cord of an animal model of motor neuron degeneration.},
  author={Pietro Ghezzi and Renato Bernardini and Rosario Giuffrida and Maria Bellomo and Claudia Manzoni and D Comoletti and E. Di Santo and Fabio Benigni and Tiziana Mennini},
  journal={European cytokine network},
  year={1998},
  volume={9 2},
  pages={139-44}
}
Autoimmunity and oxidative/excitotoxic damage are considered as possible pathogenetic mechanisms in amyotrophic lateral sclerosis (ALS). As tumor necrosis factor (TNF) is implicated in autoimmune diseases, including experimental autoimmune encephalomyelitis, and can be neurotoxic, we studied TNF production in a proposed animal model of ALS, the mnd mouse. These mice develop symptoms (progressive weakness of the limbs) as late as at 7 months of age. We measured TNF in serum, brain and spinal… CONTINUE READING

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