Tumor necrosis factor is cytotoxic to human fibroblasts in the presence of exogenous arachidonic acid.

@article{Hori1989TumorNF,
  title={Tumor necrosis factor is cytotoxic to human fibroblasts in the presence of exogenous arachidonic acid.},
  author={Takamitsu Hori and S Kashiyama and Morisada Hayakawa and Sayumi Shibamoto and Masafumi Tsujimoto and Naoto Oku and Fumiaki Ito},
  journal={Experimental cell research},
  year={1989},
  volume={185 1},
  pages={41-9}
}
Recombinant human tumor necrosis factor (TNF) stimulated the growth of confluent human fibroblasts (FS-4) in serum-free culture medium. However, TNF had a cytotoxic effect upon the growth of FS-4 cells in combination with arachidonic acid. When arachidonic acid was added to culture medium in the absence of TNF, however, it had no effect on the cell growth. Arachidonic acid inhibited the TNF-induced cell growth in a dose-dependent manner: it reversed the TNF-stimulated growth to the control… CONTINUE READING