Tumor necrosis factor induces Bcl-2 and Bcl-x expression through NFkappaB activation in primary hippocampal neurons.

@article{Tamatani1999TumorNF,
  title={Tumor necrosis factor induces Bcl-2 and Bcl-x expression through NFkappaB activation in primary hippocampal neurons.},
  author={Michio Tamatani and Yong Ho Che and Hitomi Matsuzaki and Satoshi Ogawa and Haruo Okado and Satoshi Miyake and Takeshi Mizuno and Masaya Tohyama},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 13},
  pages={8531-8}
}
Emerging data indicate that tumor necrosis factor (TNF) exerts a neuroprotective effect in response to brain injury. Here we examined the mechanism of TNF in preventing neuronal death in primary hippocampal neurons. TNF protected neurons against hypoxia- or nitric oxide-induced injury, with an increase in the anti-apoptotic proteins Bcl-2 and Bcl-x as determined by Western blot and reverse transcriptase-polymerase chain reaction analysis. Treatment of neurons with an antisense oligonucleotide… CONTINUE READING
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