Tumor necrosis factor-induced nonapoptotic cell death requires receptor-interacting protein-mediated cellular reactive oxygen species accumulation.

@article{Lin2004TumorNF,
  title={Tumor necrosis factor-induced nonapoptotic cell death requires receptor-interacting protein-mediated cellular reactive oxygen species accumulation.},
  author={Yong Lin and Swati Choksi and Han-ming Shen and Q Yang and Gang Min Hur and You Sun Kim and Jamie Hong Tran and Sergei A. Nedospasov and Zheng-gang Liu},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 11},
  pages={10822-8}
}
The mechanism of tumor necrosis factor (TNF)-induced nonapoptotic cell death is largely unknown, although the mechanism of TNF-induced apoptosis has been studied extensively. In wild-type mouse embryonic fibroblast cells under a caspase-inhibited condition, TNF effectively induced cell death that morphologically resembled necrosis. In this study, we utilized gene knockout mouse embryonic fibroblasts cells and found that tumor necrosis factor receptor (TNFR) I mediates TNF-induced necrotic cell… CONTINUE READING
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