Corpus ID: 3236196

Tumor necrosis factor-induced hepatocyte apoptosis precedes liver failure in experimental murine shock models.

@article{Leist1995TumorNF,
  title={Tumor necrosis factor-induced hepatocyte apoptosis precedes liver failure in experimental murine shock models.},
  author={M. Leist and F. Gantner and I. Bohlinger and G. Tiegs and P. Germann and A. Wendel},
  journal={The American journal of pathology},
  year={1995},
  volume={146 5},
  pages={
          1220-34
        }
}
We investigated the role of hepatocyte apoptosis in four different murine models of acute inflammatory liver failure. Liver damage induced in D-galactosamine-sensitized mice by endotoxin infection was initiated by processes typical of apoptosis, ie, chromatin condensation, DNA fragmentation, and formation of intracellular apoptotic bodies. DNA was cleaved into oligonucleosomal fragments in the liver before a significant rise of alanine aminotransferase in plasma occurred. Passive immunization… Expand
DNA fragmentation in mouse organs during endotoxic shock.
Transgenic Expression of Cyclooxygenase-2 in Hepatocytes Accelerates Endotoxin-Induced Acute Liver Failure1
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