Tumor necrosis factor increases transcription of the heparin-binding epidermal growth factor-like growth factor gene in vascular endothelial cells.

@article{Yoshizumi1992TumorNF,
  title={Tumor necrosis factor increases transcription of the heparin-binding epidermal growth factor-like growth factor gene in vascular endothelial cells.},
  author={Masanori Yoshizumi and Stella Kourembanas and D H Temizer and Richard Paul Cambria and Thomas Quertermous and Margaret E. Lee},
  journal={The Journal of biological chemistry},
  year={1992},
  volume={267 14},
  pages={9467-9}
}
Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is a recently identified, potent vascular smooth muscle cell (SMC) mitogen of macrophage origin. To determine whether this gene is transcribed and regulated in vascular endothelial cells, we measured HB-EGF mRNA levels in human umbilical vein endothelial cells (HUVEC) by RNA blot analysis… CONTINUE READING