Tumor necrosis factor blockers influence macrophage responses to Mycobacterium tuberculosis.

@article{Harris2008TumorNF,
  title={Tumor necrosis factor blockers influence macrophage responses to Mycobacterium tuberculosis.},
  author={James Harris and Jayne C Hope and Joseph Keane},
  journal={The Journal of infectious diseases},
  year={2008},
  volume={198 12},
  pages={1842-50}
}
Tumor necrosis factor (TNF)-alpha is a proinflammatory cytokine that mediates inflammation in response to various pathogens, including Mycobacterium tuberculosis, but is also a key factor in the pathogenesis of rheumatoid arthritis and other autoimmune diseases. Three TNF-alpha-suppressing drugs have been approved to treat selected autoimmune diseases; 2 are monoclonal antibodies against TNF-alpha (adalimumab and infliximab), and the other is a soluble TNF receptor/Fc fusion protein (etanercept… CONTINUE READING
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