Tumor necrosis factor-beta induces sleep, fever, and anorexia.

  title={Tumor necrosis factor-beta induces sleep, fever, and anorexia.},
  author={Levente Kap{\'a}s and James M. Krueger},
  journal={The American journal of physiology},
  volume={263 3 Pt 2},
The enhanced sleep, fever, and anorexia experienced during general infections are attributed to the increased production of cytokines. Cytokines such as interleukin-1 and tumor necrosis factor-alpha (TNF-alpha) have characteristic somnogenic, pyrogenic, and anorectic effects. TNF-beta is closely related to TNF-alpha, and they share common receptors. The effects of TNF-beta on sleep-wake activity, brain temperature (Tbr), and food intake were, however, heretofore unknown. We injected 0.5-200 ng… CONTINUE READING


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